For ease of calculation of dosage regimens, many clinicians rely on nomograms to calculate the proper dosage regimen for their patients. The use of a nomogram may give a quick dosage regimen adjustment for patients with characteristics requiring adjustments, such as age, body weight, and physiologic state. In general, the nomogram of a drug is based on population pharmacokinetic data collected and analyzed using a specific pharmacokinetic model. In order to keep the dosage regimen calculation simple, complicated equations are often solved and the results displayed diagrammatically on special scaled axes to produce a simple dose recommendation based on patient information. Some nomograms make use of certain physiologic parameters, such as serum creatinine concentration, to help modify the dosage regimen according to renal function.

This topic describes: Nomograms and Tabulations in designing dosage regimen, Conversion from intravenous to oral dosing, Determination of dose and dosing intervals, Drug dosing in the elderly and pediatrics and obese patients.

Design of dosage regimens

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