Increased rate of removal of an agent to reduce mortality, complications, more invasive interventions, or LOS. In practice useful only when positive risk-benefit analysis and, Severe toxicity, Poor outcome despite supportive care/antidote, Slow endogenous rate of elimination and Suitable pharmokinetic properties
This topic describes: Forced Diuresis, Extracorporeal techniques – Haemodialysis, Haemoperfusion, Peritoneal dialysis, Haemofiltration, Plasmapheresis, Plasma perfusion and Cardiopulmonary bypass.