Clinical symptoms and management of acute poisoning of Non-steroidal anti-inflammatory drugs (NSAIDs): NSAID overdose is not generally associated with significant morbidity. Occasionally, large ingestions are reported to cause coma, metabolic acidosis, acute renal failure, bradycardia, hypotension, seizures, or death. Mefenamic acid causes seizures much more commonly than other NSAIDs. There is no specific antidote and treatment is generally supportive. Activated charcoal and generous fluid replacement is usually all that is required.
This topic describes: Classification, Toxicity Level, Mechanism, Clinical (Toxic) Symptoms, Investigations/Diagnosis, Management of NSAIDs Poisoning Specific.