Toxicokinetics is essentially the study of “how a substance gets into the body and what happens to it in the body.” Before this term was used, the study of the kinetics (movement) of chemicals was originally conducted with pharmaceuticals and the term pharmacokinetics became commonly used. Similarly, toxicology studies were initially conducted with drugs. Toxicokinetics deals with what the body does with a drug when given a relatively high dose relative to the therapeutic dose. Read more about differences between pharmacokinetics and toxicokinetics.

This topic describes: Toxicokinetics Processes, Factors Determining the Severity of Toxicity, Inter-Related Processes of Absorption, Distribution, Biotransformation, and Elimination, Toxicokinetics Parameters and Clinical Applications. Toxicokinetics of Paracetamol – Mechanism, Kinetics in overdose and Clinical Effects.


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