Chapter 1: General Pharmacology

QUESTIONS:

1. Write a note on pharmacodynamic drug interaction.
2. Write a note on pharmacokinetic drug interaction.
3. Write a note on preclinical evaluation
4. Explain Drug tolerance in detail
5. Write a note on drug dependence and explain its mechanism
6. Factors affecting drug actions
7. Write a note on drug interactions.
8. Explain different mechanisms of drug absorption
9. Explain the factors affecting absorption.
10. Explain Phase-I metabolism in detail
11. Explain Phase-II metabolism in detail
12. Explain the factors affecting metabolism of drugs
13. Write different routes of administration along with their merits & demerits
14. Explain the different phases of clinical trials
15. Define bioavailability? Explain the factors affecting bioavailability.
16. Write a note on mechanism of drug action.
17. Write a note on G-protein coupled receptors
18. Write a note on different types of receptors
19. Explain the factors affecting drug action
20. Importance of plasma protein binding
21. Define subacute toxicity with example
22. Give any two examples for acute toxicity
23. Define Prodrug
24. Define First pass effect
25. Define Therapeutic index
26. Define Bioequivalence
27. Explain Child dose calculation
28. Define cross tolerance with example
29. Define iontophoresis and its uses
30. What are the different Source of drugs
31. Define Drug dependence & Drug abuse
32. Explain Tachyphylaxis
33. What are Adverse drug reactions? Give Example.
34. Define Apparent volume of distribution
35. Define Additive effects with examples
36. Define synergistic effects with examples
37. Enlist Cholinergic receptors
38. Define Dose response relationship
39. Merits & Demerits of Intrathecal route of administration
40. Define Competitive antagonism with example
41. Define non-Competitive antagonism with example
42. Define Placebo
43. Merits & Demerits of nasal route of administration
44. Merits & Demerits of sublinguial route of administration