Tobacco is one of the most widely abused substances in the world. It is highly addictive. The Centers for Disease Control and Prevention estimates that tobacco causes 6 million deaths per year. This makes tobacco the leading cause of preventable death. Nicotine is the main addictive chemical in tobacco. It causes a rush of adrenaline when absorbed in the bloodstream or inhaled via cigarette smoke. Nicotine also triggers an increase in dopamine. This is sometimes referred to as the brain’s “happy” chemical.
This topic describes: Sources, Active Principles – Nicotine, Nornicotine, Anabasine and Anabatine, Mode of Intake, Mechanism, Clinical (Toxic) Symptoms, Health consequences of tobacco use, Nicotine withdrawal, Investigations, and Management of Tobacco abuse.